Direct and Regioselective C−H Selenylation of 4‐Aminocoumarin Derivatives Mediated by Selectfluor®

Abstract

AbstractA mild and regioselective approach to the direct selenylation of 4‐(N‐substituted‐amino)‐2H‐chromen‐2‐ones employing Selectfluor® and diorganyl diselenides has been developed. The reactions were carried out under metal‐free conditions, without the need for special devices, and using NaHCO3 as a mild base at room temperature under air. This approach has been suitable for a wide substrate scope affording the 3‐selenyl‐4‐(N‐substituted‐amino)‐2H‐chromen‐2‐ones in good to excellent yields.