Affiliation:
1. Institute of Chemical Technology Vietnam Academy of Science and Technology No.1 A, TL29 Street, Thanh Loc Ward, District 12 Ho Chi Minh City Vietnam
2. Graduate University of Science and Technology Vietnam Academy of Science and Technology No.18, Hoang Quoc Viet Street, Cau Giay District Hanoi Vietnam
3. Ton Duc Thang University No. 19 Nguyen Huu Tho Str., Tan Phong Ward, Dist. 7 Ho Chi Minh City Vietnam
4. International University, Vietnam National University Block 6, Linh Trung Ward, Thu Duc District Ho Chi Minh City Vietnam
Abstract
AbstractDiosmetin (DT) exhibits various biological activities, including anticancer, antibacterial, antioxidant, estrogenic, and, most notably, anti‐inflammatory properties. Although it has a great deal of promise for advancement in therapeutic usage, DT has yet to be the subject of many applicable investigations in the realm of pharmacology or medicine in oral or dermal form due to the drawback of being insoluble in water. In this study, the fabrication of carboxymethyl cellulose/polyvinyl alcohol (CMC/PVA) nanofibers loaded with diosmetin (DT) using an electrospinning process was conducted to increase the solubility of DT. After electrospinning, PVA, CMC, and DT are a combination under fixed conditions, providing nano DT fibres having a smooth, homogeneous, non‐granular shape and uniform size of P11C2DT fibre (151 nm) with 82.8 % drug loading efficiency. The nanofibrous membrane P11C2DT was characterized via several physicochemical analyses, including scanning electron microscopy (SEM), Fourier‐transform infrared (FT‐IR), X‐ray diffraction (XRD), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). Specifically, the nanofibrous membrane carrier dissolved approximately 85 % of the medication in the release medium after 5 h, starkly contrasting to the powdered form of DT, which did not dissolve in the test environment.