Synthesis and Anticancer Activities of some Ag(I) Complexes Involving N‐Heterocyclic Carbene Ligands

Author:

Mageed Ahmed Hassoon1ORCID,Hadi Israa Sami2

Affiliation:

1. The University of Kufa Faculty of Science Department of Chemistry P.O. Box 21, An Najaf 54001 Iraq

2. The University of Kufa Faculty of pharmacy P.O. Box 21, An Najaf 54001 Iraq

Abstract

AbstractA new study focused on the synthesis of silver(I)‐N‐heterocyclic carbene complexes. The mono‐Ag(I)‐NHC complexes were successfully synthesized in high yield using a direct complexation method, which involved an excess of Ag2O and imidazolium salts (R= butyl, methylacetate) in dichloromethane. The bis‐Ag(I)‐NHC complexes, on the other hand, were synthesized using a 1 : 2 ratio of Ag2O and imidazolium salts. The ligands and resulting complexes were thoroughly characterized using analytical techniques such as FT‐IR, NMR spectroscopy, LC–MS and elemental analysis. Subsequently, the synthesized complexes were tested against MCF7 breast cancer cells. The results of the study highlighted the remarkable anticancer potential exhibited by the Ag(I)‐NHC complexes against breast cancer cells. Interestingly, it was observed that the mono Ag(I) NHC complexes demonstrated greater potency, with IC50 values ranging from 5 to 13.5 μg/mL, when compared to their bis‐Ag(I)‐NHC counterparts.

Funder

Ministry of Higher Education and Scientific Research

Publisher

Wiley

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