Hydration of Nitriles to Amides under In situ Nano‐Pd Catalysis in PEG‐400

Abstract

AbstractAn additive free, simple and efficient in situ PdNPs in PEG‐400 catalyzed and acetamide mediated hydration of nitriles to amides with broad substrate scope was developed herein for the first time. The in situ PdNPs recovered after first catalytic cycle of nitrile hydration sequence have been reused successively for four times.