Affiliation:
1. Department of Chemistry, Faculty of Sciences University of Guilan PO Box 41335-1914 Rasht Iran
Abstract
AbstractAn in‐situ strategy is reported for the transition‐metal‐free oxidation of a benzylic H‐pair to perform Csp3−Csp3 bond formation. This study used sixteen benzylic and quasi benzylic reactants of primary and secondary alkyl aryl compounds, e. g., toluene, pyridine, and quinoline derivatives, to perform an oxidative coupling reaction via convenient air oxygen (O2) and MeOH‐KOH solution with a yield of 0–98 %. We now report using an in‐situ green transition‐metal‐free oxidative coupling strategy for C−C bond formation. In other attempts, metal‐catalyzed oxidation of the benzylic sp3 C−H bond of the methylquinoline has been done to perform the sp3 functionalization reaction. The reaction of 2‐methylqunioline with phenylacetylene in the presence of CuCl catalyst completed to isoxazole linkage product.