Affiliation:
1. Department of Medicinal Chemistry and Pharmacognosy College of Pharmacy Qassim University Qassim 51452 Saudi Arabia
2. Department of Pharmacognosy and Medicinal Plants Faculty of Pharmacy Al-Azhar University Cairo 11371 Egypt.
3. Department of Applied Sciences University of Technology Baghdad 10066 Iraq
4. Department of Chemistry College of Science University of Misan Maysan 62001 Iraq.
5. Department of Molecular and Medical Biotechnology College of Biotechnology Al-Nahrain University, Jadriya Baghdad Iraq
6. Department of Pharmacognosy Faculty of Pharmacy University of Benghazi Benghazi Libya
7. Department of pharmacognosy Faculty of Pharmacy Assalam International University Benghazi Libya
Abstract
AbstractChrysin, the natural bioactive flavone compound, has been identified in several edible materials such as honey, propolis, and passionflower with numerous biological potentials and pharmaceutical effects including antitumor, anti‐inflammatory, antiviral and antioxidant. The compound has been reported to have lower in vitro antioxidant activity compared to other flavone‐based structures such as quercetin, luteolin, and myricetin, which is mostly attributed to the higher hydroxylation and the presence of conjugated en‐diol structures in these flavonoids and the lack of these structural features in chrysin. On the contrary to the in vitro antioxidant effect of chrysin, the compound has exerted remarkable in vivo antioxidant activities in several models related to the liver, brain, heart, kidneys, and other soft tissues. The current review includes a discussion of the in vivo and in vitro antioxidant activity of chrysin compared to other common flavonoids. The study also covers subjects linked to chrysin antioxidants, such as its metabolism, bioavailability, and current formulations that aim to increase chrysin antioxidant impact and overcome its low bioavailability.
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