Metal‐Free Regioselective Oxidative C−H Trifluoromethylation of Imidazothiazoles and Their Antitubercular Activity-Reference-Cited by-同舟云学术

Metal‐Free Regioselective Oxidative C−H Trifluoromethylation of Imidazothiazoles and Their Antitubercular Activity

Published:2024-03-21 Issue:12 Volume:9 Page:
ISSN:2365-6549
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Author:

Chirra Nagaraju¹²,Shanigarapu Varshitha¹²,Pedapati Ravi Kumar¹²,Varakala Saiprasad Dasugari³,Bollikanda Rakesh K.¹²,Sriram Dharmarajan³,Sridhar Balasubramanian²⁴,Kantevari Srinivas¹²^ORCID

Affiliation:

1. Fluoro and Agrochemicals Department CSIR-Indian Institute of Chemical Technology Hyderabad 500007 India

2. Academy of Scientific and Innovative Research Ghaziabad 201002 India

3. Medicinal Chemistry and Antimycobacterial Research Laboratory, Pharmacy Group Birla Institute of Technology & Science-Pilani Hyderabad, Campus, Jawahar Nagar Hyderabad 500078, Telangana India

4. Centre for X-ray Crystallography CSIR-Indian Institute of Chemical Technology Hyderabad 500007 India.

Abstract

AbstractHere we report a metal‐free direct C−H trifluoromethylation of the imidazothiazoles 7(a–ad) using sodium triflouromethanesulfinate (Langlois’ reagent) and tert‐butyl hydroperoxide (TBHP) as an oxidant. The control studies show that the protocol follows the radical reaction pathway and provides excellent yields of trifluoromethylated products 9(a–ad) with broad substrate scope and regioselective operation. Moreover, the newly synthesized compounds exhibit promising antimycobacterial activity.

Publisher

Wiley

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