Affiliation:
1. Department of Applied Chemistry School of Applied Natural Sciences Adama Science & Technology University Adama Ethiopia
2. Department of Prosthodontics Saveetha Dental College & Hospital Saveetha Institute of Medical and Technical Science (SIMAT) Saveetha University 600077 Chennai Tamil Nadu India
3. Drug Discovery Research Trichy Ayurvedic Union Pvt. Ltd. Tiruchirappalli Tamil Nadu India 620017
Abstract
AbstractMetal‐based therapeutic strategies have been effectively used to treat a number of diseases since the ancient period. However, the issue that emerged at this time was the indistinct barrier between therapeutic and toxic doses. After the discovery of cisplatin, a breakthrough was made for these challenges, and vital signs of progress were shown in the medicinal potential of metal complexes. Consequently, nowadays many metal‐based drugs, especially in cancer treatments, are under investigation. Nevertheless, due to a greater focus on clinical relevance, a few of these drugs are currently approved, and many more are in clinical trials waiting for approval. Therefore, the design, development, and clinical applications of several metal‐based anti‐cancer agents and their efficacy are highlighted in this review. Moreover, this review is intended to present a comprehensive overview of metal‐based anticancer agents, their targets of drug design and development and their mechanisms of action in cancer treatments.
Funder
Adama Science and Technology University
Cited by
6 articles.
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