Affiliation:
1. School of Pharmacy and Technology Management SVKM's NMIMS Hyderabad 509301 Telangana India
2. Department of Chemistry Maharishi Markandeshwar University, Mullana Ambala 133207 Haryana India
3. Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management SVKM's NMIMS Mumbai 400056 India
4. School of Pharmaceutical Sciences Apeejay Stya University Gurugram 122103 Haryana India
5. Department of Pharmaceutical Sciences School of Health Sciences and Technology UPES Dehradun 248007 Uttarakhand India
Abstract
AbstractNitrogen‐bearing heterocycles are ubiquitous in landscapes and have a great impact on living nature. Structural motifs are present in diverse natural products like vitamins, antibiotics, and alkaloids, as well as pharmaceuticals. The 1,3,5‐Triazines are the primitive class of heterocyclic motifs and are used in various synthetic and medicinal applications. This review covers an exhaustive exploration of literature reports and describes various synthetic strategies and pharmacological activities of 1,3,5‐triazine moiety. Synthetic strategies include multicomponent reaction, metal catalyst reaction, microwave‐assisted strategy, etc. to construct 1,3,5‐triazine moiety. Pharmacological activities include anticancer, antimalarial, antibacterial, antifungal, antiviral, anti‐tubercular, anti‐leishmanial, anti‐inflammatory, histamine antagonist, serotonin antagonist, etc. For anticancer activity, 1,3,5‐triazine moiety‐containing compounds were tested on different cell lines, and inhibitory activity was also mentioned. The involvement of this scaffold in the treatment of various diseases and disorders makes this scaffold important from a research perspective. Therefore, there is a need to present the combined data of research and reviews to the researchers to develop new molecules. For that reason, the review included information from articles published from 1978 onwards.