Impact of Poly (Vinyl Alcohol) on The Thermogelation Property and Drug Release Profile of Ophthalmic Formulations Based on Poloxamer 407

Abstract

AbstractIn this study, we have designed and assessed a Ketorolac tromethamine (KT) based thermally responsive in situocular gelling system. These gelling systems consist of a thermally responsive in situ gelling polymer, poloxamer 407 (PM) and different molecular weight of poly (vinyl alcohol) (PVA) as release retardant. The formulations were analyzed for sol‐gel transition temperature, gelling aptitude, viscosity and rheological studies, gel morphology study, gel dissolution property and in vitro drug release study. FTIR spectral analysis was performed to explore any polymer‐polymer or drug‐polymer association. In comparison to commercially available drugs, the new formulations present a longer‐lasting drug release profile.