Detection of Flunitrazepam in Biological Fluids and Beverages:A Review

Author:

Chen Siyu1,Huang Weibo1,Qiu Yunliang2,Zhang Xueji3,Kong Jinming1ORCID

Affiliation:

1. School of Environmental and Biological Engineering Nanjing University of Science and Technology 210094 Nanjing China

2. Department of Criminal Science and Technology Nanjing Forest Police College 210023 Nanjing China

3. School of Biomedical Engineering Shenzhen University Health Science Center 518060 Shenzhen China

Abstract

AbstractFlunitrazepam, a very potent benzodiazepine with sedative, hypnotic and amnesic effects, is commonly used to treat severe insomnia and as an anesthetic. Due to these characteristics, when flunitrazepam is sneaked into alcohol or drinks, it is often highly associated with violent behavior and drug rape cases. Therefore, it is also known as a “date rape drug”, and the detection of flunitrazepam and its metabolites is of great interest in forensic medicine and pharmacotoxicology. This paper describes the mechanism of action and drug metabolism process of flunitrazepam, reviews the different methods for detecting flunitrazepam published over the years, summarizes the detection limits of each method and compares their advantages and disadvantages. We hope to provide some inspiration for future research in this field.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

General Chemistry

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