Epidermal Growth Factor Receptor Inhibiting 4‐Aminoquinazolines as Promising Anticancer Agents: A Patent Review (2000‐Present)

Author:

Patel Rahul V.1ORCID,Mistry Bhupendra M.1,Gujarati Akash V.2,Patel Amit B.3,Patel Divyesh K.2

Affiliation:

1. Department of Food Science and Biotechnology Dongguk University-Seoul, Ilsandong-gu Goyang-si, Gyenggi-do 410820, Republic of Korea

2. Department of Chemistry The Maharaja Sayajirao University of Baroda Vadodara 390002 India

3. Department of Chemistry Government College Daman (Affiliated to Veer Narmad South Gujarat University Surat) Daman India- 396210

Abstract

AbstractCancer is now recognized as a major threat to global health and a notable cause of human mortality. Rapid cell multiplication abilities and the unchecked cell expansion that develops from a single cell define it. The epidermal growth factor receptor is a member of the ERBB family of receptors (ERBB‐1/2/3/4), and cancer can occur due to EGFR mutations. A lot of research is now being done on 4‐aminoquinazolines to suppress EGFR. With FDA‐approved medications based on the 4‐aminoquinazoline core already in use, we think that this core holds a lot of promise for a novel type of cancer therapy with significant therapeutic benefits. In this patent review, we have surveyed a huge number of patents reported (2000‐present) involving 4‐aminoquinazoline core as an anticancer agent targeting EGFR. We attempt here, with a huge body of literature based on this core, to update researchers about the latest EGFR‐targeted developments utilizing 4‐aminoquinazolines, which will provide support for the development of novel kinase‐targeted cancer therapies.

Publisher

Wiley

Subject

General Chemistry

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