Affiliation:
1. Department of Biological Sciences and Engineering Indian Institute of Technology Gandhinagar Palaj 382355 Gujarat India
2. Biomedical EngineeringDepartment Texas A&M University College Station 77840 Texas USA
3. Biological and Life Sciences School of Arts and Sciences Central Campus Ahmedabad University Navrangpura 380009 Gujarat India
Abstract
AbstractMetastatic breast cancer is a significant clinical challenge calling for novel and efficient therapeutic approaches. DNA tetrahedron, a highly programmable nanocage, offers some promising attributes including biocompatibility, stability, and functionalization making it an attractive candidate for drug delivery. In this study, we have explored the potential of DNA tetrahedron as a carrier of doxorubicin, a DNA and RNA synthesis‐inhibiting chemotherapy drug. We have encapsulated doxorubicin in DNA tetrahedron (TD : Dox) and subsequently focused on metastatic breast cancer cells for the effect of the same. We showed that TD : Dox has the potential to inhibit the migration of cancerous cells in the 2D model and inhibit the invasion of tumor cells in the 3D model as well. This system also can be uptaken in in vivo zebrafish model as well. Overall, this study promises the TD : Dox system as an ideal drug delivery model and a viable approach for metastatic breast cancer treatment.
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