Hemophagocytic lymphohistiocytosis accompanying Still's disease: A case report

Author:

Ahmadzadeh Arman1,Babadi Neda2ORCID,Farsad Faraneh3ORCID,Babadi Saba4,Assar Shirin5ORCID

Affiliation:

1. Rheumatology Ward of Loghman Hakim Hospital Shahid Beheshti University of Medical Sciences Tehran Iran

2. Department of Adult Rheumatology, Loghman Hakim Hospital, School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran

3. Research Centre of Loghman Hakim Hospital Shahid Beheshti University of Medical Sciences Tehran Iran

4. Department of Adult Internal Medicine Naft Grand Hospital Ahvaz Iran

5. Clinical Research Development Center, Imam Reza Hospital Kermanshah University of Medical Sciences Kermanshah Iran

Abstract

Key Clinical MessageHemophagocytic lymphohistiocytosis (HLH) is a rare hematologic disease that occurs due to immune system dysfunction. Clinical manifestations of this disease are fever, increased ferritin level, cytopenia, and hemophagocytosis in the biopsy report of the bone marrow. We report a 36‐year‐old woman referred to our hospital with persistent fever, arthralgia in interphalangeal joints, and cutaneous rash on the trunk, was subsequently diagnosed as an adult‐onset Still's disease (AOSD), and after bone marrow aspiration, HLH was diagnosed with her.

Publisher

Wiley

Subject

General Medicine

Reference15 articles.

1. Haemophagocytic syndrome in rheumatic patients. A systematic review;Atteritano M;Eur Rev Med Pharmacol Sci,2012

2. Autoimmune-associated hemophagocytic syndrome

3. Incidence and clinical presentation of primary hemophagocytic lymphohistiocytosis in Sweden

4. HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis

5. Hemophagocytic syndrome secondary to adult‐onset still's disease but very similar to lymphoma;Zhang X‐H;Int J Clin Exp Pathol,2012

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