Management of unspecified anxiety disorder: Expert consensus

Author:

Sakurai Hitoshi1ORCID,Inada Ken2ORCID,Aoki Yumi3ORCID,Takeshima Masahiro4,Ie Kenya56,Kise Morito7,Yoshida Eriko8,Tsuboi Takashi1,Yamada Hisashi9,Hori Hikaru10,Inada Yasushi11,Shimizu Eiji1213,Mishima Kazuo4,Watanabe Koichiro1,Takaesu Yoshikazu114ORCID

Affiliation:

1. Department of Neuropsychiatry Kyorin University Faculty of Medicine Tokyo Japan

2. Department of Psychiatry, School of Medicine Kitasato University Kanagawa Japan

3. Psychiatric and Mental Health Nursing St. Luke's International University Tokyo Japan

4. Department of Neuropsychiatry Akita University Graduate School of Medicine Akita Japan

5. Division of General Internal Medicine, Department of Internal Medicine St. Marianna University School of Medicine Kanagawa Japan

6. Division of General Internal Medicine, Department of Internal Medicine Kawasaki Municipal Tama Hospital Kanagawa Japan

7. Centre for Family Medicine Development Japanese Health and Welfare Co‐operative Federation Tokyo Japan

8. Department of General Internal Medicine, Kawasaki Kyodo Hospital Kawasaki Health Cooperative Association Kanagawa Japan

9. Department of Neuropsychiatry Hyogo Medicial University Hyogo Japan

10. Department of Psychiatry, Faculty of Medicine Fukuoka University Fukuoka Japan

11. Medical corporation YUJIN‐KAI Inada Clinic Osaka Japan

12. Research Center for Child Mental Development Chiba University Chiba Japan

13. Department of Cognitive Behavioral Physiology, Graduate School of Medicine Chiba University Chiba Japan

14. Department of Neuropsychiatry, Graduate School of Medicine University of the Ryukyus Okinawa Japan

Abstract

AbstractAimsTreatment guidelines with respect to unspecified anxiety disorder have not been published. The aim of this study was to develop a consensus among field experts on the management of unspecified anxiety disorder.MethodsExperts were asked to evaluate treatment choices based on eight clinical questions concerning unspecified anxiety disorder using a nine‐point Likert scale (1 = “disagree” to 9 = “agree”). According to the responses from 119 experts, the choices were categorized into first‐, second‐, and third‐line recommendations.ResultsBenzodiazepine anxiolytic use was not categorized as a first‐line recommendation for the primary treatment of unspecified anxiety disorder, whereas multiple nonpharmacological treatment strategies, including coping strategies (7.9 ± 1.4), psychoeducation for anxiety (7.9 ± 1.4), lifestyle changes (7.8 ± 1.5), and relaxation techniques (7.4 ± 1.8), were categorized as first‐line recommendations. Various treatment strategies were categorized as first‐line recommendations when a benzodiazepine anxiolytic drug did not improve anxiety symptoms, that is, differential diagnosis (8.2 ± 1.4), psychoeducation for anxiety (8.0 ± 1.5), coping strategies (7.8 ± 1.5), lifestyle changes (7.8 ± 1.5), relaxation techniques (7.2 ± 1.9), and switching to selective serotonin reuptake inhibitors (SSRIs) (7.0 ± 1.8). These strategies were also highly endorsed when tapering the dosage of or discontinuing benzodiazepine anxiolytic drugs. There was no first‐line recommendation regarding excusable reasons for continuing benzodiazepine anxiolytics.ConclusionsThe field experts recommend that benzodiazepine anxiolytics should not be used as a first‐line option for patients with unspecified anxiety disorder. Instead, several nonpharmacological interventions and switching to SSRIs were endorsed for the primary treatment of unspecified anxiety disorder and as alternatives to benzodiazepine anxiolytics.

Publisher

Wiley

Subject

Pharmacology (medical),Psychiatry and Mental health,Pharmacology,Clinical Psychology

Reference21 articles.

1. Anxiety disorders

2. The German guidelines for the treatment of anxiety disorders

3. World Federation of Societies of biological psychiatry (WFSBP) guidelines for treatment of anxiety, obsessive‐compulsive and posttraumatic stress disorders ‐ version 3. Part I: anxiety disorders;Bandelow B;World J Biol Psychiatry,2022

4. National Institute for health and clinical excellence (NICE).Generalised anxiety disorder and panic disorder in adults: Management.2011. Available from:https://www.nice.org.uk/guidance/cg113

5. Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the treatment of panic disorder, social anxiety disorder and generalised anxiety disorder

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1. Clinical practice for unspecified anxiety disorder in primary care;Psychiatry and Clinical Neurosciences Reports;2023-06-28

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