Computationally-predicted CB1 cannabinoid receptor mutants show distinct patterns of salt-bridges that correlate with their level of constitutive activity reflected in G protein coupling levels, thermal stability, and ligand binding-Reference-Cited by-同舟云学术

Computationally-predicted CB1 cannabinoid receptor mutants show distinct patterns of salt-bridges that correlate with their level of constitutive activity reflected in G protein coupling levels, thermal stability, and ligand binding

Published:2013-06-14 Issue:8 Volume:81 Page:1304-1317
ISSN:0887-3585
Container-title:Proteins: Structure, Function, and Bioinformatics
language:en
Short-container-title:Proteins

Author:

Ahn Kwang H.¹,Scott Caitlin E.²,Abrol Ravinder²,Goddard William A.²,Kendall Debra A.¹

Affiliation:

1. Department of Pharmaceutical Sciences; University of Connecticut; Storrs; Connecticut

2. Materials and Process Simulation Center; California Institute of Technology; Pasadena; California

Publisher

Wiley

Subject

Molecular Biology,Biochemistry,Structural Biology

Reference93 articles.

1. International Union of Pharmacology. XXVII. Classification of cannabinoid receptors;Howlett;Pharmacol Rev,2002

2. A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor;Lean;J Biol Chem,1980

3. A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model;Samama;J Biol Chem,1993

4. Inverse agonist activity of beta-adrenergic antagonists;Chidiac;Mol Pharmacol,1994

5. Active site-directed inactivation of constitutively active mutants of rhodopsin;Govardhan;J Biol Chem,1994

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