Available evidence on fetal liver changes detected by ultrasound in pregnant women with gestational diabetes mellitus: Systematic review

Author:

Da Correggio Karine Souza1ORCID,Galluzzo Roberto Noya1ORCID,von Wangenheim Aldo2ORCID,Werner Heron3ORCID,Castro Pedro Teixeira3ORCID,Araujo Júnior Edward45ORCID,Onofre Alexandre Sherlley Casimiro6ORCID

Affiliation:

1. Division of Tocogynecology, University Hospital Polydoro Ernani of São Thiago Federal University of Santa Catarina (UFSC) Florianópolis Brazil

2. Brazilian Institute for Digital Convergence Federal University of Santa Catarina (UFSC) Florianópolis Brazil

3. Department of Fetal Medicine Biodesign Laboratory DASA/PUC Rio de Janeiro Brazil

4. Department of Obstetrics Paulista School of Medicine ‐ Federal University of São Paulo (EPM‐UNIFESP) São Paulo Brazil

5. Discipline of Woman Health Municipal University of São Caetano do Sul (USCS) São Caetano do Sul Brazil

6. Department of Clinical Analyses Federal University of Santa Catarina (UFSC) Florianópolis Brazil

Abstract

AbstractThe aim of this systematic review was to examine the available scientific literature on ultrasound‐detected fetal liver changes in pregnant women with gestational diabetes mellitus (GDM) and to explore the potential of these markers to inform clinical management and improve outcomes. A total of four articles investigating fetal liver changes in GDM pregnancies were selected. The studies varied in methodology, gestational age studied, and diagnostic criteria for GDM. Fetal liver indices, such as fetal liver length and fetal liver volume, emerged as potential markers for identifying GDM and predicting adverse outcomes. Studies suggest an association between fetal liver changes and GDM, with implications for both maternal glycemic control and fetal metabolic adaptation. Variability in study methodology highlights the need for standardized approaches to assess fetal hepatic indices and their correlation with GDM outcomes.

Publisher

Wiley

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