Renal Transporter‐Mediated Drug‐Biomarker Interactions of the Endogenous Substrates Creatinine and N <sup>1</sup> ‐Methylnicotinamide: A PBPK Modeling Approach-Reference-Cited by-同舟云学术

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Renal Transporter‐Mediated Drug‐Biomarker Interactions of the Endogenous Substrates Creatinine and N ¹ ‐Methylnicotinamide: A PBPK Modeling Approach

Published:2022-06-07 Issue:3 Volume:112 Page:687-698
ISSN:0009-9236
Container-title:Clinical Pharmacology & Therapeutics
language:en
Short-container-title:Clin Pharma and Therapeutics

Author:

Türk Denise¹^ORCID,Müller Fabian²,Fromm Martin F.²^ORCID,Selzer Dominik¹,Dallmann Robert³^ORCID,Lehr Thorsten¹^ORCID

Affiliation:

1. Clinical Pharmacy Saarland University Saarbrücken Germany

2. Institute of Experimental and Clinical Pharmacology and Toxicology Friedrich‐Alexander‐Universität Erlangen‐Nürnberg Erlangen Germany

3. Division of Biomedical Sciences Warwick Medical School University of Warwick Coventry UK

Funder

Bundesministerium für Bildung und Forschung

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.2636

Reference49 articles.

1. A pharmaceutical industry perspective on transporter and CYP-mediated drug–drug interactions: kidney transporter biomarkers

2. Drug‐Drug Interactions Involving Renal OCT2/MATE Transporters: Clinical Risk Assessment May Require Endogenous Biomarker‐Informed Approach

3. Protein Abundance of Clinically Relevant Drug Transporters in The Human Kidneys

4. Prediction of Transporter-Mediated Drug–Drug Interactions Using Endogenous Compounds

5. Serum Creatinine and Renal Function

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2. Innovative Approaches to Optimize Clinical Transporter Drug–Drug Interaction Studies;Pharmaceutics;2024-07-26

3. Utilising Endogenous Biomarkers in Drug Development to Streamline the Assessment of Drug–Drug Interactions Mediated by Renal Transporters: A Pharmaceutical Industry Perspective;Clinical Pharmacokinetics;2024-06

4. Impact of 1α,25-dihydroxyvitamin D3 on biodistribution and pharmacokinetics of L-carnitine and creatinine, organic cation/carnitine transporter 2 and organic cation transporter 2 biomarkers;Journal of Pharmaceutical Investigation;2024-02-07

5. Identification and characterization of an endogenous biomarker of the renal vectorial transport (OCT2‐MATE1);Biopharmaceutics & Drug Disposition;2024-02

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