Transcatheter aortic valve replacement in heart failure

Author:

Parikh Puja B.1,Mack Michael2,Stone Gregg W.3,Anker Stefan D.45,Gilchrist Ian C.1,Kalogeropoulos Andreas P.1,Packer Milton6,Skopicki Hal A.1,Butler Javed67

Affiliation:

1. Department of Medicine Stony Brook Renaissance School of Medicine Stony Brook NY USA

2. Department of Cardiac Surgery Baylor Scott & White Health Plano TX USA

3. Icahn School of Medicine at Mount Sinai Hospital New York NY USA

4. Department of Cardiology (CVK) and Berlin Institute of Health Center for Regenerative Therapies (BCRT), German Centre for Cardiovascular Research (DZHK), Partner Site Berlin Charité‐Universitätsmedizin Berlin Germany

5. Institute of Heart Diseases Wroclaw Medical University Wroclaw Poland

6. Baylor Heart and Vascular Institute Baylor University Medical Center Dallas TX USA

7. Baylor Scott and White Research Institute Dallas TX USA

Abstract

ABSTRACTPatients with severe aortic stenosis (AS) may develop heart failure (HF), the presence of which has traditionally been deemed as a final stage in AS progression with poor outcomes. The use of transcatheter aortic valve replacement (TAVR) has become the preferred therapy for most patients with AS and concomitant HF. With its instant afterload reduction, TAVR offers patients with HF significant haemodynamic benefits, with corresponding changes in left ventricular structure and improved mortality and quality of life. The prognostic covariates and optimal timing of TAVR in patients with less than severe AS remain unclear. The purpose of this review is to describe the association between TAVR and outcomes in patients with HF, particularly in the setting of left ventricular systolic dysfunction, acute HF, and right ventricular systolic dysfunction, and to highlight areas for future research.

Publisher

Wiley

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