Affiliation:
1. Department of Otolaryngology Icahn School of Medicine at Mount Sinai New York New York USA
2. Department of Otolaryngology Massachusetts Eye and Ear Boston Massachusetts USA
Abstract
AbstractBackgroundThis systematic review aggregates the data of studies that include site‐specific analyses of patients undergoing salvage surgery for residual or recurrent hypopharyngeal squamous cell carcinoma.MethodsThe primary outcomes are disease‐free, disease‐specific, and overall survival (DFS, DSS, and OS, respectively). Secondary outcomes include complications and postoperative feeding requirements.ResultsFifteen studies met the inclusion criteria with a total of 442 patients. Two‐year DFS is reported from 30.0 to 50.0% and 5‐year DFS ranges from 15.0 to 57.1%. Five‐year DSS ranges from 28.0 to 57.1%. Two‐year OS ranges from 38.8 to 52.0% and 5‐year OS ranges from 15.5 to 57.1%. Complications include pharyngocutaneous fistula (0.0–71.4%), carotid artery rupture (2.9–13.3%), and stomal stenosis (4.2–20.0%). Complete oral feeding achieved following surgery ranges from 61.9 to 100.0%, while complete gastrostomy tube dependence ranges from 0.0 to 28.6%.ConclusionsSalvage surgery for residual or recurrent hypopharyngeal squamous cell carcinoma has a relatively high complication rate and should be offered to patients with the understanding of a guarded prognosis.