Affiliation:
1. Department of Otolaryngology−Head and Neck Surgery Cambridge University Hospitals NHS Trust Cambridge UK
2. Department of Clinical Medicine, University of Cambridge School of Clinical Medicine Cambridge UK
3. Department of Otolaryngology−Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University of Brescia Brescia Italy
4. Cambridge University Medical Library Cambridge UK
Abstract
AbstractObjectiveThis study aims to estimate the rate of postoperative meningitis (both immediate and long‐term) in patients following cochlear implants (CIs). It aims to do so through a systematic review and meta‐analysis of published studies tracking complications after CIs.Data SourcesMEDLINE, Embase, and Cochrane Library.Review MethodsThis review was performed in line with Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. Studies tracking complications following CIs in patients were included. Exclusion criteria included non‐English language studies and case series reporting <10 patients. Bias risk was evaluated using the Newcastle‐Ottawa Scale. Meta‐analysis was performed through DerSimonian and Laird random‐effects models.ResultsA total of 116/1931 studies met the inclusion criteria and were included in the meta‐analysis. Overall, there were 112 cases of meningitis in 58,940 patients after CIs. Meta‐analysis estimated an overall rate of postoperative meningitis of 0.07% (95% confidence interval [CIs], 0.03%‐0.1%; I2 = 55%). Subgroup meta‐analysis showed this rate had 95% CIs crossing 0% in implanted patients who received the pneumococcal vaccine, antibiotic prophylaxis, those with postoperative acute otitis media (AOM), and those implanted less than 5 years.ConclusionMeningitis is a rare complication following CIs. Our estimated rates of meningitis after CIs appear lower than prior estimates based on epidemiological studies in the early 2000s. However, the rate still appears higher than the baseline rate in the general population. The risk was very low in implanted patients who received the pneumococcal vaccine, antibiotic prophylaxis, received unilateral or bilateral implantations, developed AOM, those implanted with a round window or cochleostomy techniques, and those under 5 years.
Subject
Otorhinolaryngology,Surgery
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