The effects of thymic stromal lymphopoietin and IL‐3 on human eosinophil–basophil lineage commitment: Relevance to atopic sensitization
Author:
Affiliation:
1. Division of Allergy & Clinical ImmunologyDepartment of MedicineMcMaster UniversityHamiltonOntarioCanada
Publisher
Wiley
Subject
Immunology,Immunology and Allergy
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/iid3.20
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1. The epithelium takes centre stage in asthma and atopic dermatitis
2. TSLP: finally in the limelight
3. Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells
4. Double-stranded RNA induces disproportionate expression of thymic stromal lymphopoietin versus interferon- in bronchial epithelial cells from donors with asthma
5. IL-3 and TNFα increase Thymic Stromal Lymphopoietin Receptor (TSLPR) expression on eosinophils and enhance TSLP-stimulated degranulation
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