Maslinic acid induces autophagy by down-regulating HSPA8 in pancreatic cancer cells

Author:

Tian Ye1,Xu Huanli12,Farooq Ammad Ahmad3,Nie Baozeng4,Chen Xiaoliang5,Su Shuonan1,Yuan Ru1,Qiao Gan1,Li Cong1,Li Xiao1,Liu Xiaohui1,Lin Xiukun1ORCID

Affiliation:

1. Department of Pharmacology, School of Basic Medical Sciences; Capital Medical University; Beijing 100069 China

2. Zibo Biomedicinal Institute; Zibo 255000 Shandong China

3. Laboratory for Translational Oncology and Personalized Medicine, RLMC; 35 Km Ferozepur Road Lahore Pakistan

4. Rizhao Tranditional Chinese Medical Hospital; Rizhao 276800 Shandong China

5. Basic Medical School; Datong Univeristy; Datong 037009 Shanxi China

Funder

National Natural Science Foundation of China

Project of High-level Teachers in Beijing Municipal Universities in the Period of 13th 5-year Plan

Zibo Development Program of Sci. & Tech, in Shandong, China

Natural Science Foundation and Key Res. Project of Shandong, China

National Innovative Drug Development Project of China

Publisher

Wiley

Subject

Pharmacology

Reference46 articles.

1. Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma;Aghdassi;Cancer Research,2007

2. Antioxidant and antiatherogenic activities of pentacyclic triterpenic diols and acids;Allouche;Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association,2010

3. Comparison of the activity of three different HSP70 inhibitors on apoptosis, cell cycle arrest, autophagy inhibition, and HSP90 inhibition;Budina-Kolomets;Cancer Biology & Therapy,2014

4. Targeting autophagy in cancer: Update on clinical trials and novel inhibitors;Chude;International Journal of Molecular Sciences,2017

5. Chloroquine-mediated cell death in metastatic pancreatic adenocarcinoma through inhibition of autophagy;Frieboes;JOP: Journal of the pancreas,2014

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