PTEN loss and activation of K-RAS and β-catenin cooperate to accelerate prostate tumourigenesis

Author:

Jefferies Matthew T12,Cox Adam C13,Shorning Boris Y1,Meniel Valerie1,Griffiths David4,Kynaston Howard G25,Smalley Matthew J1ORCID,Clarke Alan R1

Affiliation:

1. The European Cancer Stem Cell Research Institute, School of Biosciences; Cardiff University; Cardiff UK

2. Institute of Cancer and Genetics; Cardiff University School of Medicine; Cardiff UK

3. Department of Urology; Morriston Hospital; Swansea UK

4. Department of Pathology; University Hospital of Wales; Cardiff UK

5. Department of Urology; University Hospital of Wales; Cardiff UK

Funder

Prostate Cancer UK

Prostate Cancer Research Centre

European Cancer Stem Cell Research Institute

Cancer Research Wales

Cancer Research UK

Publisher

Wiley

Subject

Pathology and Forensic Medicine

Reference68 articles.

1. Integrative genomic profiling of human prostate cancer;Taylor;Cancer Cell,2010

2. The genomic complexity of primary human prostate cancer;Berger;Nature,2011

3. Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer;Barbieri;Nat Res,2012

4. Punctuated evolution of prostate cancer genomes;Baca;Cell,2013

5. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer;Tomlins;Science,2005

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