The Interleukin‐1 Receptor–Associated Kinase 4 Inhibitor PF‐06650833 Blocks Inflammation in Preclinical Models of Rheumatic Disease and in Humans Enrolled in a Randomized Clinical Trial

Author:

Winkler Aaron1ORCID,Sun Weiyong1,De Saurav2,Jiao Aiping1,Sharif M. Nusrat1,Symanowicz Peter T.1,Athale Shruti3,Shin Julia H.1,Wang Ju1,Jacobson Bruce A.1,Ramsey Simeon J.1,Dower Ken1,Andreyeva Tatyana1,Liu Heng1,Hegen Martin1,Homer Bruce L.1,Brodfuehrer Joanne1,Tilley Mera1,Gilbert Steven A.1,Danto Spencer I.1,Beebe Jean J.1,Barnes Betsy J.2,Pascual Virginia3,Lin Lih‐Ling1,Kilty Iain1,Fleming Margaret1,Rao Vikram R.1

Affiliation:

1. Pfizer Cambridge Massachusetts

2. The Feinstein Institute Manhasset New York

3. Baylor Institute for Immunology Research Dallas Texas

Funder

National Institutes of Health

Pfizer

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Publisher

Wiley

Subject

Immunology,Rheumatology,Immunology and Allergy

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