Association between sickle cell anemia and alpha thalassemia reveals a high prevalence of the α3.7triplication in congolese patients than in worldwide series

Author:

Mikobi Tite Minga123,Lukusa Prosper Tshilobo1456,Aloni Michel Ntetani7ORCID,Lumaka Aimé1456,Akilimali Pierre Zalagile8,Devriendt Koenraad4,Matthijs Gert4,Mbuyi Muamba Jean-Marie9,Race Valerie4

Affiliation:

1. Center for Human Genetics; Faculty of Medicine; University of Kinshasa; Kinshasa Democratic Republic of Congo

2. Department des Sciences de Bases; Laboratory of Biochemistry and Molecular Biology; Faculty of Medicine; University of Kinshasa; Kinshasa Democratic Republic of Congo

3. Sickle Cell Center of Yolo; Kinshasa Democratic Republic of Congo

4. Center for Human Genetics; Katholieke Universiteit te Leuven; Leuven Belgium

5. Department of Pediatrics; University Hospital of Kinshasa; Faculty of Medicine; University of Kinshasa; Kinshasa Democratic Republic of Congo

6. Institut National de Recherche Biomédicale; Kinshasa Democratic Republic of Congo

7. Division of Hemato-oncology and Nephrology; Department of Pediatrics; Faculty of Medicine; University of Kinshasa; Kinshasa Democratic Republic of Congo

8. Division of Biostatistics and Epidemiology; School of Public Health; University of Kinshasa; Kinshasa Democratic Republic of Congo

9. Division of Hemato-Immuno-Rheumatology; Department of Internal Medicine; Faculty of Medicine; University of Kinshasa; Kinshasa Democratic Republic of Congo

Funder

KU Leuven

Publisher

Wiley

Subject

Microbiology (medical),Biochemistry (medical),Medical Laboratory Technology,Clinical Biochemistry,Public Health, Environmental and Occupational Health,Hematology,Immunology and Allergy

Reference44 articles.

1. A specific chemical difference between the globins of normal human and sickle-cell anaemia haemoglobin;Ingram;Nature,1956

2. Predicting clinical severity in sickle cell anaemia;Steinberg;Br J Haematol,2005

3. Genetic modifiers of the beta-haemoglobinopathies;Thein;Br J Haematol,2008

4. Genetic modifiers of the severity of sickle cell anemia identified through a genome-wide association study;Sebastiani;Am J Hematol,2010

5. Fetal hemoglobin in sickle cell anemia;Akinsheye;Blood,2011

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