Metronomic chemotherapy following the maximum tolerated dose is an effective anti-tumour therapy affecting angiogenesis, tumour dissemination and cancer stem cells

Author:

Vives Marta1,Ginestà Mireia M.1,Gracova Kristina1,Graupera Mariona2,Casanovas Oriol1,Capellà Gabriel1,Serrano Teresa3,Laquente Berta,Viñals Francesc

Affiliation:

1. Translational Research Laboratory; Catalan Institute of Oncology, IDIBELL, Hospital Duran i Reynals, L'Hospitalet de Llobregat; Barcelona; Spain

2. Molecular Oncology Department; Bellvitge Biomedical Research Institute, IDIBELL, L'Hospitalet de Llobregat; Barcelona; Spain

3. Anatomy and Pathology Department; University Hospital of Bellvitge, IDIBELL, L'Hospitalet de Llobregat; Barcelona; Spain

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference27 articles.

1. Metronomic scheduling of anticancer treatment: the next generation of multitarget therapy?;Andre;Future Oncol,2011

2. Back to the basics: the importance of concentration × time in oncology;Weitman;J Clin Oncol,1993

3. Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer;Browder;Cancer Res,2000

4. Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity;Klement;J Clin Invest,2000

5. The anti-angiogenic basis of metronomic chemotherapy;Kerbel;Nat Rev Cancer,2004

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