Heterologous expression of the plant cysteine protease bromelain and its inhibitor inPichia pastoris

Author:

Luniak Nora1,Meiser Peter1ORCID,Burkart Sonja2,Müller Rolf3

Affiliation:

1. Ursapharm Arzneimittel GmbH; Industriestraße 35 Saarbrücken 66129 Germany

2. PharmBioTec GmbH; Science Park 1 Saarbrücken 66123 Germany

3. Helmholtz Institute for Pharmaceutical Research Saarland, Department of Microbial Natural Products, Helmholtz Centre for Infection Research and Pharmaceutical Biotechnology at Saarland University; Saarbrücken 66041 Germany

Funder

Bundesministerium für Bildung und Forschung

Publisher

Wiley

Subject

Biotechnology

Reference73 articles.

1. Bromelain: biochemistry, pharmacology and medical use;Maurer;Cell Mol Life Sci.,2001

2. Effects of oral bromelain administration on the impaired immunocytotoxicity of mononuclear cells from mammary tumor patients;Eckert;Oncol Rep.,1999

3. Bromelain proteases suppress growth, invasion and lung metastasis of B16F10 mouse melanoma cells;Grabowska;Int J Oncol.,1997

4. Isolation and partial characterization of basic proteinases from stem bromelain;Harrach;J Protein Chem.,1995

5. Bromelain protease F9 reduces the CD44 mediated adhesion of human peripheral blood lymphocytes to human umbilical vein endothelial cells;Munzig;FEBS Lett.,1994

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