Nonhormonal selective estrogen receptor modulator 1-(2-[4-{(3R,4S)-7-Methoxy-2, 2-dimethyl-3-phenyl-chroman-4yl}phenoxy]ethyl)pyrrolidine hydrochloride (ormeloxifene hydrochloride) for the treatment of breast cancer

Author:

Pillai Lakshmi Sreedharan1,Regidi Saikant1,Varghese Shiny Deena1,Ravindran Shilpa1,Maya Vani1,Varghese Jesline1,Ramaswami Kartik1,Gopimohan Rajmohan1,Gopi Manoj1ORCID

Affiliation:

1. Cell Culture & Clinical Research Facility, Corporate R&D Centre; HLL Lifecare Limited; Trivandrum India

Funder

HLL Lifecare Limited

WOS-A Scheme, Department of Science and Technology, Government of India

Publisher

Wiley

Subject

Drug Discovery

Reference52 articles.

1. PEGylated chitosan nanoparticles potentiate repurposing of ormeloxifene in breast cancer therapy;Agrawal;Nanomedicine,2016

2. Ormeloxifene-induced unfolded protein response contributes to autophagy-associated apoptosis via disruption of Akt/mTOR and activation of JNK;Arindam;Scientific Reports,2018

3. Role of poly (ADP-ribose) polymerase (PARP) cleavage in apoptosis Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells;Boulares;The Journal of Biological Chemistry,1999

4. Tamoxifen and risk of idiopathic venous thromboembolism;Christoph;British Journal of Clinical Pharmacology,1998

5. Early breast cancer Trialists collaborative group (EBCTCG), relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: Patient-level meta-analysis of randomised trials;Davies;Lancet,2011

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