Functional Brain Networks of Minor and Well‐Structured Major Hallucinations in Parkinson's Disease

Author:

Baik Kyoungwon1ORCID,Kim Yae Ji23ORCID,Park Mincheol45ORCID,Chung Seok Jong5,Sohn Young H.5,Jeong Yong236ORCID,Lee Phil Hyu57ORCID

Affiliation:

1. Department of Neurology Anam Hospital, Korea University College of Medicine Seoul South Korea

2. Program of Brain and Cognitive Engineering Korea Advanced Institute of Science and Technology Daejeon South Korea

3. KI for Health Science and Technology Korea Advanced Institute of Science and Technology Daejeon South Korea

4. Department of Neurology Chung‐Ang University College of Medicine and Graduate School of Medicine, Gwangmyeong Hospital Gwangmyeong South Korea

5. Department of Neurology Yonsei University College of Medicine Seoul South Korea

6. Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology Daejeon South Korea

7. Severance Biomedical Science Institute Yonsei University College of Medicine Seoul South Korea

Abstract

AbstractBackgroundMinor hallucinations (mHs) and well‐structured major hallucinations (MHs) are common symptoms of Parkinson's disease (PD) psychosis.ObjectivesTo investigate the resting‐state networks (RSNs) in patients with PD without hallucinations (PD‐nH), with mH (PD‐mH), and with MH (PD‐MH).MethodsA total of 73 patients with PD were enrolled (27 PD‐nH, 23 PD‐mH, and 23 PD‐MH). Using seed‐based functional connectivity analyses, we investigated the RSNs supposedly related to hallucinations in PD: the default mode network (DMN), executive control network (ECN), dorsal attention network (DAN), ventral attention network (VAN), and visual network (VN). We compared the cognitive function and RSN connectivity among the three groups. In addition, we performed a seed‐to‐seed analysis to examine the inter‐network connectivity within each group using the corresponding RSN seeds.ResultsPD‐MH group had lower test scores for attention and visuospatial functions compared with those in the other groups. The connectivity of the right intracalcarine cortex within the DAN was lower in the PD‐MH group than in the others. The PD‐mH and PD‐MH groups showed higher connectivity in the left orbitofrontal cortex within DMN compared with the PD‐nH group, whereas the connectivity was lower in the right middle frontal gyrus (MFG) within ECN, precuneus cortex within VAN, right middle temporal gyrus and precuneus cortex within DAN, and left MFG within VN. The PD‐mH and PD‐MH groups showed different inter‐network connectivity between the five RSNs, especially regarding DAN connectivity.ConclusionsDAN dysfunction may be a key factor in the progression from mH to MH in patients with PD. © 2023 International Parkinson and Movement Disorder Society.

Publisher

Wiley

Subject

Neurology (clinical),Neurology

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