Braiding Three‐Dimensional Paper‐Based Microfluidic Devices

Author:

Jia Cuiyun123,Li Bin1,Pan Jie1,Zhu Fengjiao1,Bai Xue1,Liu Xianming1,Lin Bingcheng1,Chen Yahong23,Lu Yao1ORCID

Affiliation:

1. Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China

2. College of Chemistry & Green Catalysis Center Zhengzhou University Zhengzhou 450001 China

3. College of Chemistry & Chemical Engineering Zhoukou Normal University Zhoukou 46001 China

Abstract

AbstractThree‐dimensional paper‐based microfluidic devices have shown great potential in various applications, including point‐of‐care diagnostics, environmental monitoring, and tissue engineering. However, their fabrication is still limited to stacking and origami methods. Inspired by the art of bamboo braiding in China, we developed a novel fabrication technique based on the braiding concept to create three‐dimensional paper‐based microfluidic devices with PDMS‐impregnated paper substrate as the building units. The resulting three‐dimensional paper device brings unique advantages, including compactness, facile disassembly, and real‐time flow visualization. The multiplexed glucose analysis with a braided device integrated with 16‐switchable valves for flow control was further fabricated to demonstrate the device‘s applicability. We envision braiding‐based fabrication technology opening new possibilities and bringing broad applications for three‐dimensional paper microfluidic devices.

Funder

National Natural Science Foundation of China

Youth Innovation Promotion Association of the Chinese Academy of Sciences

Dalian Institute of Chemical Physics, Chinese Academy of Sciences

Publisher

Wiley

Subject

General Medicine

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