Direct Electrooxidative Selenylamination of Alkynes: Access to 3‐Selenylindoles-Reference-Cited by-同舟云学术

Direct Electrooxidative Selenylamination of Alkynes: Access to 3‐Selenylindoles

Published:2023-07-24 Issue: Volume: Page:
ISSN:0021-2148
Container-title:Israel Journal of Chemistry
language:en
Short-container-title:Israel Journal of Chemistry

Author:

Hasimujiang Balati¹,Zeng Yong¹,Zou Shifeng¹,Zhong Kaihui¹,Su Lebin²,Hu Xinwei¹,Ruan Zhixiong¹^ORCID

Affiliation:

1. Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease School of Pharmaceutical Sciences & the Fifth Affiliated Hospital Guangzhou Medical University Guangzhou 511436 P. R. China.

2. Guangzhou Laboratory Guangzhou 510320 P. R. China.

Abstract

AbstractA novel metal‐ and oxidant‐free electrooxidative selenylamination of o‐aminophenacetylenes with diselenides for achieving 3‐selenylindoles has been developed with moderate to excellent yield. The reaction proceeded smoothly with a broad substrate scope and highly functional group tolerance. The synthetic practicality of this innovative approach was demonstrated by its easy scalability. Moreover, mechanistic studies revealed that an in‐situ generated selenium cation might be the key intermediate for the electrochemical selenocyclization process.

Funder

National Natural Science Foundation of China

Basic and Applied Basic Research Foundation of Guangdong Province

Publisher

Wiley

Subject

General Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijch.202300088

Reference62 articles.

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