Free-energy computations identify the mutations required to confer trans-sialidase activity intoTrypanosoma rangelisialidase

Author:

Pierdominici-Sottile Gustavo1,Palma Juliana1,Roitberg Adrian E.2

Affiliation:

1. Departamento de Ciencia y Tecnología; Universidad Nacional de Quilmes; Saenz Peña 352 Bernal B1876BXD Argentina

2. Department of Chemistry and Quantum Theory Project; University of Florida; Gainesville Florida 32611-7200

Publisher

Wiley

Subject

Molecular Biology,Biochemistry,Structural Biology

Reference52 articles.

1. Trypanosoma cruzi surface mucins: host-dependent coat diversity;Buscaglia;Nat Rev Micro,2006

2. Invasive phenotype of Trypanosoma cruzi restricted to a population expressing trans-sialidase;Pereira;Infect Immun,1996

3. Mucin-like molecules form a negatively charged coat that protects Trypanosoma cruzi trypomastigotes from killing by human anti-alpha-galactosyl antibodies;Pereira-Chioccola;J Cell Sci,2000

4. Structural and functional properties of Trypanosoma trans-sialidase;Schenkman;Annu Rev Microbiol,1994

5. Metacyclic neutralizing effect of monoclonal antibody 10D8 directed to the 35- and 50-kilodalton surface glycoconjugates of Trypanosoma cruzi;Yoshida;Infect Immun,1989

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