Histone demethylase <scp>PHF8</scp> promotes prostate cancer metastasis via the <scp>E2F1</scp>–<scp>SNAI1</scp> axis-Reference-Cited by-同舟云学术

Histone demethylase PHF8 promotes prostate cancer metastasis via the E2F1–SNAI1 axis

Published:2024-07-18 Issue:1 Volume:264 Page:68-79
ISSN:0022-3417
Container-title:The Journal of Pathology
language:en
Short-container-title:The Journal of Pathology

Author:

Wang Ze¹,Tang Peng¹,Xiao Haiyang¹,Peng Song¹,Chen Jian¹,Wang Yapeng¹,Xu Jing¹,Yan Qian¹,Zhang Junying²³,Deng Jie¹,Ma Qiang¹,Zhu Hailin¹,Luo Weiming¹,Zhang Dianzheng⁴,Wang Luofu¹,Qin Jun⁵,Lan Weihua¹,Jiang Jun¹^ORCID,Liu Qiuli¹^ORCID

Affiliation:

1. Department of Urology, Daping Hospital Army Medical University Chongqing PR China

2. Chongqing Key Laboratory of High Active Traditional Chinese Drug Delivery System, Chongqing Engineering Research Center of Pharmaceutical Sciences Chongqing Medical and Pharmaceutical College Chongqing PR China

3. College of Pharmacy Chongqing Medical University Chongqing PR China

4. Department of Bio‐Medical Sciences Philadelphia College of Osteopathic Medicine Philadelphia PA USA

5. CAS Key Laboratory of Tissue Microenvironment and Tumor, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Nutrition and Health Sciences, Chinese Academy of Sciences University of Chinese Academy of Sciences Shanghai PR China

Abstract

AbstractMetastasis is the primary culprit behind cancer‐related fatalities in multiple cancer types, including prostate cancer. Despite great advances, the precise mechanisms underlying prostate cancer metastasis are far from complete. By using a transgenic mouse prostate cancer model (TRAMP) with and without Phf8 knockout, we have identified a crucial role of PHF8 in prostate cancer metastasis. By complexing with E2F1, PHF8 transcriptionally upregulates SNAI1 in a demethylation‐dependent manner. The upregulated SNAI1 subsequently enhances epithelial‐to‐mesenchymal transition (EMT) and metastasis. Given the role of the abnormally activated PHF8/E2F1‐SNAI1 axis in prostate cancer metastasis and poor prognosis, the levels of PHF8 or the activity of this axis could serve as biomarkers for prostate cancer metastasis. Moreover, targeting this axis could become a potential therapeutic strategy for prostate cancer treatment. © 2024 The Pathological Society of Great Britain and Ireland.

Funder

National Natural Science Foundation of China

Publisher

Wiley

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