Affiliation:
1. State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University Changsha Hunan 410082 P. R. China
2. Department of Chemistry The Hong Kong University of Science and Technology, Clear Water Bay Kowloon Hong Kong SAR P. R. China
Abstract
AbstractEnamines are formed by reacting a carbonyl compound with an amine under dehydration conditions. A vast array of transformations has been achieved via preformed enamine chemistry. Recently, by introducing conjugating double bonds to the enamine functionality, dienamines, and trienamines have propelled the discovery of several previously unattainable remote‐site functionalization reactions of carbonyl compounds. Comparatively, alkyne‐conjugating enamine analogues have recently shown high potential in multifunctionalization reactions while remaining underexplored. In this account, we systematically summarized and discussed recent advances in synthetic transformations based on ynenamine‐containing compounds.
Funder
National Outstanding Youth Science Fund Project of National Natural Science Foundation of China
National Natural Science Foundation of China
Natural Science Foundation of Hunan Province
Subject
Materials Chemistry,General Chemical Engineering,Biochemistry,General Chemistry