Affiliation:
1. Key Laboratory of Organofluorine Chemistry Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences 345 Ling-Ling Road Shanghai 200032 China
2. Key Laboratory of Energy Regulation Materials Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 Ling-Ling Road Shanghai 200032 China
Abstract
AbstractThe NMR technique is among the most powerful analytical methods for molecular structural elucidation, process monitoring, and mechanistic investigations; however, the direct analysis of complex real‐world samples is often hampered by crowded NMR spectra that are difficult to interpret. The combination of fluorine chemistry and supramolecular interactions leads to a unique detection method named recognition‐enabled chromatographic (REC) 19F NMR, where interactions between analytes and 19F‐labeled probes are transduced into chromatogram‐like 19F NMR signals of discrete chemical shifts. In this account, we summarize our endeavor to develop novel 19F‐labeled probes tailored for separation‐free multicomponent analysis. The strategies to achieve chiral discrimination, sensitivity enhancement, and automated analyte identification will be covered. The account will also provide a detailed discussion of the underlying principles for the design of molecular probes for REC 19F NMR where appropriate.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Science and Technology Commission of Shanghai Municipality
Subject
Materials Chemistry,General Chemical Engineering,Biochemistry,General Chemistry
Cited by
2 articles.
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