Affiliation:
1. Key Laboratory of Theoretical Organic Chemistry and Functional Molecule of Ministry of Education Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers School of Chemistry and Chemical Engineering Hunan University of Science and Technology Xiangtan Hunan 411201 China
2. State Key Laboratory of Chemo/Biosensing and Chemometrics Advanced Catalytic Engineering Research Centre of the Ministry of Education College of Chemistry and Chemical Engineering Hunan University Changsha 410082 P. R. China.
Abstract
AbstractOrganic cycles play an important role in chemistry, pharmacology and material science for their unique properties. Construction of organic cycles from thioalkynes attracted increasing attention due to the facile access of thioalkynes. 2H‐Azirines were synthesized successfully from thioalkynyl oxime ethers. Cyclobutanes were formed through chiral titanium catalyzed cycloaddition of thioalkynes. Cyclopentenes were afforded by annulation of thioalkynes. Thioalkynes could be also applied to synthesize thiophenes, oxazoles, benzo[b]thiophenes, 2H‐chromenes, 2‐phenylbenzothiazoles, diazacyclobutene, etc. In this review, construction of organic cycles from thioalkynes were highlighted. Firstly, the property and application of organic cyclic compounds were simply introduced. After presenting the general methods to access organic cycles, applications of thioalkynes as synthons to prepare organic cycles were classified and presented in detail. Based on different kinds of organic cycles obtained from thioalkynes, organic reactions for synthesis of three‐, four‐, five‐, six‐membered as well as fused cycles would be summarized and the plausible reaction mechanisms could be presented if available.
Funder
National Natural Science Foundation of China
Subject
Materials Chemistry,General Chemical Engineering,Biochemistry,General Chemistry