Affiliation:
1. BioCIS UMR 8076 CNRS Building Henri Moissan Université Paris-Saclay, 17 avenue des sciences 91400 Orsay France
Abstract
AbstractThis review provides a recent overview of the different synthetic routes of the N‐CF3 group. This scaffold can be prepared from the desulfurization of thiocabamoyl fluorides or isothiocyanates with fluoride ions. Electrophilic and radical trifluoromethylations are also a great way to generate this motif. This report also focuses on the valorization of some N‐CF3 compounds, which leads to new unknown N‐trifluoromethyl derivatives. Finally, the first metabolic stability studies will be given for certain structures.
Subject
Materials Chemistry,General Chemical Engineering,Biochemistry,General Chemistry
Cited by
3 articles.
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