Fluoroalkyl Sulfoximines for Versatile Photocatalytic Radical Fluoroalkylations

Abstract

AbstractFluoroalkyl sulfoximines, which serve as electron‐accepting fluoroalkyl radical sources, are easy‐to‐handle, solid, and bench‐stable chemicals. Fluoroalkyl radicals can be generated from sulfoximine reagents using strong one‐electron injectors, such as a highly reducing photoredox catalyst in the excited state. Our group has developed photocatalytic radical di‐ and mono‐fluoromethylation and α‐monofluoroalkylation of olefins with the corresponding fluoroalkyl sulfoximines. In this personal account, appropriate combinations of fluoroalkyl sulfoximines and photoredox catalysts, leading to successful radical fluoroalkylation, have been discussed.