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Metabolic stability and determination of cytochrome P450 isoenzymes' contribution to the metabolism of medetomidine in dog liver microsomes

  • Published:2009 Issue: Volume: Page:n/a-n/a
  • ISSN:0269-3879
  • Container-title:Biomedical Chromatography
  • language:en
  • Short-container-title:Biomed. Chromatogr.

Author:

Duhamel Marie-Claude,Troncy Éric,Beaudry Francis

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference40 articles.

1. Pharmacokinetic drug interactions of synthetic opiate analgesics;Armstrong;Psychosomatics,2009

2. Differences in hepatic cytochrome P450 activity correlate with the strain-specific biotransformation of medetomidine in AX/JU and IIIVO /JU inbred rabbits;Avsaroglu;Journal of Veterinary Pharmacology and Therapeutics,2008

3. Statistical evaluation of linearity and non linearity of LC-MS/MS quantitation analysis;Beaudry;Pharmaceutical Science,1999

4. Metabolite profiling study of propranolol in rat using LC/MS/MS analysis;Beaudry;Biomedical Chromatography,1999

5. Cardiovascular and pulmonary effects of a new sedative/analgesic (medetomidine) as a preanaesthetic drug in the dog;Bergstrom;Acta Veterinaria Scandinavica,1988

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