Similar substrate specificity of cynomolgus monkey cytochrome P450 2C19 to reported human P450 2C counterpart enzymes by evaluation of 89 drug clearances-Reference-Cited by-同舟云学术

Similar substrate specificity of cynomolgus monkey cytochrome P450 2C19 to reported human P450 2C counterpart enzymes by evaluation of 89 drug clearances

Published:2015-12 Issue:9 Volume:36 Page:636-643
ISSN:0142-2782
Container-title:Biopharmaceutics & Drug Disposition
language:en
Short-container-title:Biopharm. Drug Dispos.

Author:

Hosaka Shinya¹²,Murayama Norie¹,Satsukawa Masahiro²,Uehara Shotaro¹,Shimizu Makiko¹,Iwasaki Kazuhide³,Iwano Shunsuke¹⁴,Uno Yasuhiro³,Yamazaki Hiroshi¹

Affiliation:

1. Showa Pharmaceutical University; Machida Tokyo 194-8543 Japan

2. Kaken Pharmaceutical Co., LTD.; Shizuoka 426-8646 Japan

3. Shin Nippon Biomedical Laboratories, Ltd; Kainan Wakayama 642-0017 Japan

4. Novartis Pharma K.K.; Tokyo 106-8618 Japan

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology,General Medicine

Reference33 articles.

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4. CYP2C76, a novel cytochrome P450 in cynomolgus monkey, is a major CYP2C in liver, metabolizing tolbutamide and testosterone;Uno;Mol Pharmacol,2006

5. Identification and characterization of CYP2C18 in the cynomolgus macaque (Macaca fascicularis);Uno;J Vet Med Sci,2010

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