Sex differences in associations between <i>APOE ε2</i> and longitudinal cognitive decline-Reference-Cited by-同舟云学术

Sex differences in associations between APOE ε2 and longitudinal cognitive decline

Published:2023-03-30 Issue:10 Volume:19 Page:4651-4661
ISSN:1552-5260
Container-title:Alzheimer's & Dementia
language:en
Short-container-title:Alzheimer's & Dementia

Author:

Wood Madeline E.¹²,Xiong Lisa Y.¹³,Wong Yuen Yan¹³,Buckley Rachel F.⁴⁵⁶,Swardfager Walter¹³,Masellis Mario¹⁷,Lim Andrew S. P.¹⁷,Nichols Emma⁸,Joie Renaud La⁹,Casaletto Kaitlin B.⁹,Kumar Raj G.¹⁰,Dams‐O'Connor Kristen¹⁰¹¹,Palta Priya¹²,George Kristen M.¹³,Satizabal Claudia L.¹⁴¹⁵,Barnes Lisa L.¹⁶,Schneider Julie A.¹⁶,Binet Alexa Pichette¹⁷,Villeneuve Sylvia¹⁸¹⁹²⁰,Pa Judy²¹,Brickman Adam M.²²,Black Sandra E.¹⁷,Rabin Jennifer S.¹²⁷²³,

Affiliation:

1. Hurvitz Brain Sciences Program Sunnybrook Research Institute Toronto Ontario Canada

2. Rehabilitation Sciences Institute University of Toronto Toronto Ontario Canada

3. Department of Pharmacology & Toxicology University of Toronto Toronto Ontario Canada

4. Department of Neurology, Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA

5. Florey Institute University of Melbourne Parkville Victoria Australia

6. Melbourne School of Psychological Sciences University of Melbourne Parkville Victoria Australia

7. Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre University of Toronto Toronto Ontario Canada

8. Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore Maryland USA

9. Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences University of California San Francisco California USA

10. Department of Rehabilitation and Human Performance Icahn School of Medicine at Mount Sinai New York New York USA

11. Department of Neurology Icahn School of Medicine at Mount Sinai New York New York USA

12. Departments of Medicine and Epidemiology Columbia University Irving Medical Center New York New York USA

13. Department of Public Health Sciences University of California Davis School of Medicine Davis California USA

14. Department of Population Health Science and Biggs Institute for Alzheimer's and Neurodegenerative Diseases UT Health San Antonio San Antonio Texas USA

15. Department of Neurology Boston University School of Medicine Boston Massachusetts USA

16. Rush Alzheimer's Disease Center Rush University Medical Center Chicago Illinois USA

17. Clinical Memory Research Unit, Faculty of Medicine Lund University Lund Sweden

18. Centre for Studies on Prevention of Alzheimer's Disease (StoP‐AD), Douglas Mental Health University Institute Centre for Studies on the Prevention of Alzheimer's Disease (StoP‐AD) Montreal Quebec Canada

19. Department of Psychiatry McGill University Montreal Quebec Canada

20. McConnell Brain Imaging Centre Montreal Neurological Institute Montreal Quebec Canada

21. Mark and Mary Stevens Neuroimaging and Informatics Institute Department of Neurology, University of Southern California Los Angeles California USA

22. Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, College of Physicians and Surgeons Columbia University New York New York USA

23. Harquail Centre for Neuromodulation Sunnybrook Health Sciences Centre Toronto Ontario Canada

Abstract

AbstractINTRODUCTIONWe examined whether sex modifies the association between APOE ε2 and cognitive decline in two independent samples.METHODSWe used observational data from cognitively unimpaired non‐Hispanic White (NHW) and non‐Hispanic Black (NHB) adults. Linear mixed models examined interactive associations of APOE genotype (ε2 or ε4 carrier vs. ε3/ε3) and sex on cognitive decline in NHW and NHB participants separately.RESULTSIn both Sample 1 (N = 9766) and Sample 2 (N = 915), sex modified the association between APOE ε2 and cognitive decline in NHW participants. Specifically, relative to APOE ε3/ε3, APOE ε2 protected against cognitive decline in men but not women. Among APOE ε2 carriers, men had slower decline than women. Among APOE ε3/ε3 carriers, cognitive trajectories did not differ between sexes. There were no sex‐specific associations of APOE ε2 with cognition in NHB participants (N = 2010).DISCUSSIONIn NHW adults, APOE ε2 may protect men but not women against cognitive decline.Highlights

We studied sex‐specific apolipoprotein E (APOE) ε2 effects on cognitive decline.

In non‐Hispanic White (NHW) adults, APOE ε2 selectively protects men against decline.

Among men, APOE ε2 was more protective than APOE ε3/ε3.

In women, APOE ε2 was no more protective than APOE ε3/ε3.

Among APOE ε2 carriers, men had slower decline than women.

There were no sex‐specific APOE ε2 effects in non‐Hispanic Black (NHB) adults.

Funder

Canadian Institutes of Health Research

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

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