Analysis of infantile fibrosarcoma reveals extensive T-cell responses within tumors: Implications for immunotherapy

Author:

Zhu Hua1ORCID,Gu Song2,Yin Minzhi3,Shi Min1,Xin Chao1,Zhu Jianmin1,Wang Jing2,Huang Siqi2,Xie Chenjie2,Ma Jing3,Pan Ci4,Tang Jingyan4,Xu Min2,Bai Xue-Feng15

Affiliation:

1. Pediatric Translational Medicine Research Institute; Shanghai Jiao Tong University School of Medicine; Shanghai China

2. Department of General Surgery/Surgical Oncology Center; Shanghai Children's Medical Center; Shanghai Jiao Tong University School of Medicine; Shanghai China

3. Department of Pathology; Shanghai Jiao Tong University School of Medicine; Shanghai China

4. Department of Hematology and Oncology; Shanghai Children's Medical Center; Shanghai Jiao Tong University School of Medicine; Shanghai China

5. Department of Pathology and Comprehensive Cancer Center; The Ohio State University Medical Center; Columbus Ohio

Funder

National Natural Science Foundation of China

Shanghai Jiao Tong University

Medical Guidance Project of Shanghai Committee of Science and Technology

Publisher

Wiley

Subject

Oncology,Hematology,Pediatrics, Perinatology and Child Health

Reference30 articles.

1. Infantile fibrosarcoma;Chung;Cancer.,1976

2. Infantile fibrosarcoma: management based on the European experience;Orbach;J Clin Oncol.,2010

3. ETV6-NTRK3 gene fusions and trisomy 11 establish a histogenetic link between mesoblastic nephroma and congenital fibrosarcoma;Knezevich;Cancer Res,1998

4. Evaluation of a congenital infantile fibrosarcoma by comprehensive genomic profiling reveals an LMNA-NTRK1 gene fusion responsive to crizotinib;Wong;J Natl Cancer Inst,2016

5. Infantile fibrosarcoma with NTRK3-ETV6 fusion successfully treated with the tropomyosin-related kinase inhibitor LOXO-101;Nagasubramanian;Pediatr Blood Cancer,2016

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