Growth Hormone‐Releasing Hormone: Discovery, Regulation, and Actions

Abstract

AbstractThe sections in this article are:Historical AspectsBiological Evidence for a Hypothalamic Growth Hormone–Releasing FactorPurificationAnatomical LocalizationCentral Nervous SystemExtracranialAtypicalMolecular Biology and Chemistry of Hypothalamic Growth Hormone–Releasing HormoneGene ExpressionPeptide ProcessingGrowth Hormone–Releasing Hormone ActionsGrowth Hormone–Releasing Hormone ReceptorSignal‐Transduction PathwaysRegulation of Growth Hormone–Releasing Hormone Receptor Synthesis and ActivityAdditional ActionsRegulation of Growth Hormone–Releasing Hormone Synthesis and SecretionHypothalamic Negative‐Feedback Effects of Growth HormoneGlucocorticoidsGonadal SteroidsNeurotransmittersSignal‐Transduction Pathways which Lead to Growth Hormone–Releasing Hormone ReleaseOntogenesis and Senescence of the Hormone‐Receptor SystemMetabolic ChangesFuture Directions