Quantitative Analyses of Hepatic OATP-Mediated Interactions Between Statins and Inhibitors Using PBPK Modeling With a Parameter Optimization Method-Reference-Cited by-同舟云学术

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Quantitative Analyses of Hepatic OATP-Mediated Interactions Between Statins and Inhibitors Using PBPK Modeling With a Parameter Optimization Method

Published:2016-07-28 Issue:5 Volume:100 Page:513-523
ISSN:0009-9236
Container-title:Clinical Pharmacology & Therapeutics
language:en
Short-container-title:Clin. Pharmacol. Ther.

Author:

Yoshikado T¹,Yoshida K²,Kotani N³,Nakada T⁴,Asaumi R⁵,Toshimoto K¹,Maeda K²,Kusuhara H²,Sugiyama Y¹

Affiliation:

1. Sugiyama Laboratory, RIKEN Innovation Center, RIKEN; Yokohama Kanagawa Japan

2. Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, University of Tokyo; Tokyo Japan

3. Clinical Pharmacology Strategy Group, Translational Clinical Research Science & Strategy Dept., Chugai Pharmaceutical Co.; Tokyo Japan

4. DMPK Research Laboratories Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma; Chiba Japan

5. Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co.; Ibaraki Japan

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference50 articles.

1. Cerivastatin and gemfibrozil-associated rhabdomyolysis;Bruno-Joyce;Ann. Pharmacother.,2001

2. Severe rhabdomyolysis and cerivastatin-gemfibrozil combination therapy;Roca;Ann. Pharmacother.,2002

3. Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil;Shitara;J. Pharmacol. Exp. Ther.,2004

4. Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions;Shitara;Pharmacol. Ther.,2006

5. Transporter-mediated drug-drug interactions involving OATP substrates: predictions based on in vitro inhibition studies;Yoshida;Clin. Pharmacol. Ther.,2012

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4. Modeled Hepatic/Plasma Exposures of Fluvastatin Prescribed Alone in Subjects with Impaired Cytochrome <i>P450 2C9*3</i> as One of Possible Determinant Factors Likely Associated with Hepatic Toxicity Reported in a Japanese Adverse Event Database;Biological and Pharmaceutical Bulletin;2024-03-15

5. Building a Predictive PBPK Model for Human OATP Substrates: a Strategic Framework for Early Evaluation of Clinical Pharmacokinetic Variations Using Pitavastatin as an Example;The AAPS Journal;2024-01-05

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