Protein Kinase C Isoforms Differentially Regulate Hypoxia-Inducible Factor-1α Accumulation in Cancer Cells

Author:

Kim Hyunju1,Na Yu-Ran1,Kim So Yeon12,Yang Eun Gyeong13

Affiliation:

1. Center for Theragnosis; Biomedical Research Institute; Korea Institute of Science and Technology; Hwarangno 14-gil 5 Seongbuk-gu Seoul 136-791 South Korea

2. Department of Biomedical Engineering; Korea University of Science and Technology (UST); KIST campus; Seoul 136-791 South Korea

3. Department of Biological Chemistry; Korea University of Science and Technology (UST); KIST campus; Seoul 136-791 South Korea

Funder

Multi-omics Program by Korean Ministry of Science, ICT and Future Planing

Korea Institute of Science and Technology

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference51 articles.

1. PKCalpha/beta I inhibitor Go6976 induces dephosphorylation of constitutively hyperphosphorylated Rb and G1 arrest in T24 cells;Aaltonen;Anticancer Res,2010

2. Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor;Antal;Cell,2015

3. A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets;Arsham;J Biol Chem,2003

4. Role of protein kinase Cdelta in transmitting hypoxia signal to HSF and HIF-1;Baek;J Cell Physiol,2001

5. Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls;Baud;Nat Rev Drug Discov,2009

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