Affiliation:
1. CAS Key Laboratory of Bio‐inspired Materials and Interfacial Science Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 P. R. China
2. University of Chinese Academy of Sciences Beijing 100049 P. R. China
3. Binzhou Institute of Technology Weiqiao‐UCAS Science and Technology Park Binzhou City Shandong Province 256606 P. R. China
Abstract
AbstractPolymer‐based magnetic particles have been widely used for the separation of biological samples including nucleic acids, proteins, virus, and cells. Existing magnetic particles are almost prepared by coating polymers on magnetic nanoparticles (NPs). However, this strategy usually encounters the problem of poor magnetic NPs loading capacity. Here, a series of nanofractal magnetic particles (nanoFMPs) synthesized by a strategy of mediator monomer regulated emulsion interfacial polymerization is presented, which allows effective magnetic NPs loading and show efficient nucleic acid separation performance. The mediator monomers facilitate the dispersion of magnetic NPs in internal phase to achieve higher loading, and the hydrophilic monomers use electrostatic interactions to form surface nanofractal structures with functional groups. Compared with magnetic particles without nanofractal structure, nanoFMPs exhibit a higher nucleic acid extraction capability. This strategy offers an effective and versatile way for the synthesis of nanoFMPs toward efficient separation in various fields from clinical diagnosis to food safety and environmental monitoring.
Funder
National Natural Science Foundation of China
Subject
General Materials Science,General Chemistry
Cited by
1 articles.
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