Affiliation:
1. Department of Anesthesiology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China
2. Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 101400 China
3. School of Medical Technology Beijing Institute of Technology Beijing 100081 China
4. Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 China
Abstract
AbstractMicroneedles (MNs) have emerged as a highly promising technology for delivering drugs via the skin. They provide several benefits, including high drug bioavailability, non‐invasiveness, painlessness, and high safety. Traditional strategies for intravenous delivery of anti‐tumor drugs have risks of systemic toxicity and easy development of drug resistance, while MN technology facilitates precise delivery and on‐demand release of drugs in local tissues. In addition, by further combining with stimulus‐responsive materials, the construction of smart stimulus‐responsive MNs can be achieved, which can respond to specific physical/chemical stimuli from the internal or external environment, thereby further improving the accuracy of tumor treatment and reducing toxicity to surrounding tissues/cells. This review systematically summarizes the classification, materials, and reaction mechanisms of stimulus‐responsive MNs, outlines the benefits and challenges of various types of MNs, and details their application and latest progress in cancer treatment. Finally, the development prospects of smart MNs in tumor treatment are also discussed, bringing inspiration for future precision treatment of tumors.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Natural Science Foundation of Beijing Municipality
Fundamental Research Funds for the Central Universities
Subject
General Materials Science,General Chemistry