Affiliation:
1. Department of Chemistry Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications Jinan University Guangzhou Guangdong 510632 China
2. Wens Foodstuff Group Co. Ltd Yunfu Guangdong 527400 China
Abstract
AbstractInactivated virus vaccines with whole antigen spectra and good safety are the commonly used modality for preventing infections. However, the poor immunogenicity greatly limits its clinical applications. Herein, by taking advantages of the crucial roles of Se in the functions of immune cells and its biomineralization property, it successfully in‐situ synthesized Se nanoadjuvant on inactivated viruses such as porcine epidemic diarrhea virus (PEDV), pseudorabies virus (PRV), and porcine reproductive and respiratory syndrome virus (PRRSV) in a facile method, which is universal to construct other inactivated virus vaccines. The nanovaccine can highly effectively enhance the uptake of PEDV/PRV/PRRSV into dendritic cells (DCs) and activate DCs via triggering TLR4 signaling pathways and regulating selenoproteins expressions. Furthermore, it exhibited better activities in triggering macrophages and natural killer cells‐mediated innate immunity and T cells‐mediated cellular immunity compared to PEDV and the commercial inactivated PEDV vaccine on both mice and swine models. This study provides a universal Se nanoadjuvant for developing inactivated viruses‐based nanovaccines for preventing virus infections.
Funder
National Natural Science Foundation of China
National Science Fund for Distinguished Young Scholars
Shenzhen Fundamental Research Program
Subject
General Materials Science,General Chemistry
Cited by
1 articles.
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