Affiliation:
1. Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 P. R. China
2. Shanghai Key Laboratory of Advanced Polymeric Materials School of Materials Science and Engineering East China University of Science and Technology Shanghai 200237 P. R. China
Abstract
AbstractCurrent artificial designs of the periosteum focus on osteogenic or angiogenic properties, while ignoring the filling and integration with bone microcracks, which trigger a prolonged excessive inflammatory reaction and lead to failure of bone regeneration. In this study, seamless adhesive biomimetic periosteum patches (HABP/Sr‐PLA) were prepared to fill microcracks in defective bone via interfacial self‐assembly induced by Sr ions mediated metal‐ligand interactions among pamidronate disodium‐modified hyaluronic acid (HAPD), black phosphorus (BP), and hydrophilic polylactic acid (PLA). In vitro, HABP/Sr‐PLA exhibited excellent self‐healing properties, seamlessly filled bone microcracks, and significantly enhanced osteogenesis and angiogenesis. Furthermore, in a rat cranial defect model, HABP/Sr‐PLA was demonstrated to significantly promote the formation of blood vessels and new bone under mild 808 nm photothermal stimulation (42.8 °C), and the highest protein expression of CD31 and OPN was five times higher than that of the control group and other groups. Therefore, the proposed seamless microcrack‐filled bionic periosteum patch is a promising clinical strategy for promoting bone repair.
Funder
National Basic Research Program of China
National Natural Science Foundation of China
Program of Shanghai Academic Research Leader
Subject
General Materials Science,General Chemistry