Seamlessly Adhesive Bionic Periosteum Patches Via Filling Microcracks for Defective Bone Healing

Author:

Yang Shu12,Chen Zhijie1,Zhuang Pengzhen1,Tang Yunkai1,Chen Zehao1,Wang Fei1,Cai Zhengwei1ORCID,Wei Jie2,Cui Wenguo1ORCID

Affiliation:

1. Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 P. R. China

2. Shanghai Key Laboratory of Advanced Polymeric Materials School of Materials Science and Engineering East China University of Science and Technology Shanghai 200237 P. R. China

Abstract

AbstractCurrent artificial designs of the periosteum focus on osteogenic or angiogenic properties, while ignoring the filling and integration with bone microcracks, which trigger a prolonged excessive inflammatory reaction and lead to failure of bone regeneration. In this study, seamless adhesive biomimetic periosteum patches (HABP/Sr‐PLA) were prepared to fill microcracks in defective bone via interfacial self‐assembly induced by Sr ions mediated metal‐ligand interactions among pamidronate disodium‐modified hyaluronic acid (HAPD), black phosphorus (BP), and hydrophilic polylactic acid (PLA). In vitro, HABP/Sr‐PLA exhibited excellent self‐healing properties, seamlessly filled bone microcracks, and significantly enhanced osteogenesis and angiogenesis. Furthermore, in a rat cranial defect model, HABP/Sr‐PLA was demonstrated to significantly promote the formation of blood vessels and new bone under mild 808 nm photothermal stimulation (42.8 °C), and the highest protein expression of CD31 and OPN was five times higher than that of the control group and other groups. Therefore, the proposed seamless microcrack‐filled bionic periosteum patch is a promising clinical strategy for promoting bone repair.

Funder

National Basic Research Program of China

National Natural Science Foundation of China

Program of Shanghai Academic Research Leader

Publisher

Wiley

Subject

General Materials Science,General Chemistry

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